Probabilistic Analysis and Computationally Expensive Models: Necessary and Required?
نویسندگان
چکیده
منابع مشابه
Regarding probabilistic analysis and computationally expensive models: necessary and required?
OBJECTIVE To assess the importance of considering decision uncertainty, the appropriateness of probabilistic sensitivity analysis (PSA), and the use of patient-level simulation (PLS) in appraisals for the National Institute for Health and Clinical Excellence (NICE). METHODS Decision-makers require estimates of decision uncertainty alongside expected net benefits (NB) of interventions. This re...
متن کاملUncertainty Analysis for Computationally Expensive Models with Multiple Outputs
Bayesian MCMC calibration and uncertainty analysis for computationally expensive models is implemented using the SOARS (Statistical and Optimization Analysis using Response Surfaces) methodology. SOARS uses a radial basis function interpolator as a surrogate, also known as an emulator or meta-model, for the logarithm of the posterior density. To prevent wasteful evaluations of the expensive mod...
متن کاملAn Efficient Sensitivity Analysis Approach for Computationally Expensive Microscopic Traffic Simulation Models
Microscopic traffic simulators are useful tools for designing, evaluating and optimizing transportation systems. In order for a simulator to accurately describe reality, the corresponding traffic model must be properly calibrated. However, the calibration can be rather difficult when the model is computationally expensive and has many parameters. To overcome these difficulties, Sensitivity Anal...
متن کاملComputationally secure multiple secret sharing: models, schemes, and formal security analysis
A multi-secret sharing scheme (MSS) allows a dealer to share multiple secrets among a set of participants. in such a way a multi-secret sharing scheme (MSS) allows a dealer to share multiple secrets among a set of participants, such that any authorized subset of participants can reconstruct the secrets. Up to now, existing MSSs either require too long shares for participants to be perfect secur...
متن کاملOrphan drugs: expensive yet necessary.
Whether the prices of certain orphan treatments are justified is highly controversial. One argument is that such therapies should not be funded through the public purse or private health plans because a patient with a rare disease requires more than their 'fair share' of a limited health care budget. Orphan medications can also be denied because they fare poorly in the cost-effectiveness assess...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Value in Health
سال: 2006
ISSN: 1098-3015
DOI: 10.1111/j.1524-4733.2006.00107.x